The ingredients in Cortisol Manager support healthy cortisol levels.* Cortisol is one of the most important hormones involved in the adaptation process. By supporting balanced cortisol and a healthy stress response, Cortisol Manager also promotes relaxation to support restful sleep.* THE ROLE OF CORTISOL IN TIMES OF STRESS Cortisol is a hormone produced in the adrenal cortex that is released during times of stress. Variations in cortisol secretion can indicate how well the body is coping with stress. Cortisol homeostasis is typically characterized by peak secretion during the early morning hours with a gradual decline throughout the day. Because of its central role as a key stress hormone, cortisol is often thought of as a bridge between stress and its health impact. WITH HERBAL INGREDIENTS The ingredients in Cortisol Manager help support a balanced, adaptive cortisol response to stress.* Cortisol Manager contains a stress-reducing proprietary blend of Sensoril® brand ashwagandha (Withania somnifera) and Suntheanine™ brand L-theanine.* A proprietary blend of Magnolia (Magnolia officinalis) and epimedium (Epimedium koreanum), as well as phosphatidylserine from soy lecithin are included in Cortisol Manager. A 2008 placebo-controlled clinical trial showed that Sensoril® ashwagandha significantly reduced serum cortisol levels and helped manage stress compared to placebo, in subjects experiencing higher levels of stress.*¹ A 2018 placebo-controlled clinical trial showed that a single intake of Suntheanine™ L-theanine significantly increased alpha brain wave activity in subjects compared to their placebo counterparts.*² Alpha brain wave activity is associated with a more relaxed mental state.*² Together the ingredients in Cortisol Manager help support relaxation, to promote restful sleep.* They also help stabilize the stress hormone cortisol to further support a healthy stress response.*