Core Support Powder 19oz (French Vanilla) by Orthomolecular

N-Acetyl Cysteine

N-acetyl cysteine (NAC) is a sulfhydryl-containing amino acid that is commonly used to support liver health. NAC protects the body from oxidative damage, increases Phase II biotransformation and enhances the normal breakdown of toxins and other metabolic by-products of the body.

Glycine

One of the six Phase II biotransformation pathways is amino acid conjugation (the attachment of amino acids to a toxin). Glycine is one of the amino acids used in this process, and it is also necessary for glutathione synthesis. Glycine preserves intracellular glutathione (GSH) concentration and protects cells from oxidative damage. This process is mediated by a protein called glycine transporter 1, or GLYT1.

Taurine

The sulfation pathway is another important Phase II detoxification pathway. In the sulfation pathway, a sulfur containing molecule attaches to the toxin to produce a compound that can be excreted from the body.

Potassium Citrate

Potassium is an essential mineral found in many fiber-rich whole foods and is important for various functions in the body, like electrolyte and acid-base balance. Potassium citrate is a citrate salt known to help regulate urinary pH levels, promote alkalinization in the blood and make the water-soluble toxins processed from biotransformation more easily excretable via the urine by the kidney.

Pomegranate Fruit Extract

The pomegranate fruit is well known for its high antioxidant levels and ability to protect tissues from free radical damage. It has been shown that pomegranates can have up to three times more antioxidants than green tea or red wine. In addition, the specialized blend of flavonoid antioxidants in pomegranate fruit extract has been shown to enhance the activity of key detoxification enzymes while supporting and protecting kidney function to increase the elimination of toxins through urinary excretion.

Watercress Extract

Watercress is a unique cruciferous vegetable that is a member of the cabbage family Brassicaceae. It is a nutrient-dense green plant that has been shown to boost the body’s detoxification mechanisms.

Lipoic Acid

Lipoic acid is a potent antioxidant that has been shown to increase glutathione, vitamin E and vitamin C levels in the body. Lipoic acid has been shown to support Phase II biotransformation by increasing the activity of enzymes, including NAD(P)H, quinone reductase and glutathione S-transferase.

Green Tea Leaf Extract

Green tea is one of the most widely consumed beverages throughout the world. One of the main polyphenols in green tea includes epigallocatechin-3-gallate (EGCG). Green tea polyphenols have been shown to increase antioxidant protection. Green tea has also been shown to enhance liver detoxification.

Rosemary Leaf Extract

Rosemary includes polyphenols that are potent antioxidants. Carnosol, an antioxidant in rosemary, induces glutathione S-transferase and other important Phase II enzymes. Rosemary essential oil and carnosol have also been shown to increase GSH levels.

Vegetable Antioxidant Blend

Core Support contains a blend of high-concentration superfood vegetables with significant antioxidant potential. The blend is high in ORAC value (oxygen radical absorbance capacity, a method of measuring antioxidant activity) and includes health-promoting compounds, like sulforaphane and glucosinolates. Cruciferous vegetables, including broccoli, kale and Brussels sprouts, increase the enzyme activity of both Phase I and Phase II biotransformation pathways.

Schisandra Berry Extract

Schisandra is an adaptogenic botanical used medicinally to help fight off the physical and mental effects of stress. Schisandra is also used to support liver health and neutralize the effects of toxin exposure. Schisandra enhances liver biotransformation pathways by increasing the levels of reduced glutathione in the liver as well as glutathione reductase and glutathione S-transferase activity.

Fiber Blend

The average recommendation for fiber intake is 25-30 g per day. Only 5% of the population meets the daily requirement. To help close the fiber intake gap and support the elimination of toxins, Core Support provides a blend of diverse fibers, which includes resistant tapioca dextrin, guar gum, flaxseed flour, glucomannan, fig and prune fiber, and arabinogalactan from larch trees. This fiber blend supports a higher level of microbial richness and diversity as well as intestinal barrier function.